Assessment report for solutions for infusion containing hydroxyethyl starch
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Anaphylaxis induced by hydroxyethyl starch during general anesthesia -A case report-
Hydroxyethyl starch (HES) solutions are synthetic non-protein colloid solutions used to treat hypovolemia. However, their use is not free from the risk of allergic reactions. A 42-year-old male was scheduled to undergo aortic-iliac-femoral bypass surgery for the treatment of arteriosclerosis obliterans. He had no history of allergy. Two hours after the start of surgery, and within minutes after...
متن کاملAcute kidney injury in cardiac surgery patients receiving hydroxyethyl starch solutions
In a retrospective study by a Canadian team [1], pentastarch infusion was a dose-related independent risk factor for acute kidney injury (AKI) after cardiac surgery. In a new retrospective cardiac surgery study by that team [2], 83% of patients received hydroxyethyl starch (HES) 130/ 0.4. For unexplained reasons, 25 to 43% of patients received both HES 130/0.4 and pentastarch. The team 'hypothe...
متن کاملInteractions between the volume effects of hydroxyethyl starch 130/0.4 and Ringer´s acetate
INTRODUCTION The turnover of Ringer´s solutions is greatly dependent on the physiological situation, such as the presence of dehydration or anaesthesia. The present study evaluates whether the kinetics is affected by previous infusion of colloid fluid. METHODS Ten male volunteers with a mean age of 22 years underwent three infusion experiments, on separate days and in random order. The experi...
متن کاملAssessment of coagulation with 6% hydroxyethyl starch 130/0.4 in cesarean section
BACKGROUND Third-generation hydroxyethyl starch (HES) solutions have been developed to minimize negative effects on hemostasis. In normal pregnancy, the coagulation activity increases, reaching a maximum around term. This study examined the effects of hemodilution with HES 130/0.4 (6%) on blood coagulation in parturients in vivo and in vitro. METHODS Forty parturients scheduled for cesarean s...
متن کاملThe effect of 6% hydroxyethyl starch and desmopressin infusion on von Willebrand factor: ristocetin cofactor activity.
Hydroxyethyl starch is commonly used as a plasma volume expander in the surgical patient. Although it is generally considered a safe plasma substitution, some reports of an acquired von Willebrand's disease-like syndrome have been documented. To examine this further, von Willebrand factor: ristocetin cofactor activity (RCoF) was measured in two groups of patients perioperatively, following hydr...
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